Class Notes

Here are some class notes for Spring 2019. For your reference, we left the notes from previous semesters below.

Lecture/Date Topic Slides and Notes Suggested Readings
01/19 - 01/26 Variation and the human genome

Denotes seminal work

Denotes review article

01/26 - 02/02 Linkage disequilibrium (LD)
02/04 - 02/09 TagSNP Selection
  • Typed up relevant class notes [PDF]
  • 4 Feb 2021 Lecture Whiteboard Notes [PDF]
  • 9 Feb 2021 Lecture Whiteboard Notes [PDF]
  • Old Notes:
  • Informativeness SNP tagging [ppt] [pdf]
  • Selecting a Maximally Informative Set of Single-Nucleotide Polymorphisms for Association Analyses Using Linkage Disequilibrium [PDF]
  • Optimal Haplotype Block-Free Selection of Tagging SNPs for Genome-Wide Association Studies [PDF]
Spectral Graph Theory and Spectral Clustering
  • New chapter, no notes yet
Coalescent Theory
  • Old Notes:
  • Urn Models, Wright Fisher, Ewens Sampling Lemma [pdf]
  • URN MODELS in GENETICS: Wright-Fisher Models and the Ewens Sampling Lemma [pdf]
  • Minichiello-durbin algorithm [pdf]
  • Mapping trait loci by use of inferred ancestral recombination graphs [HTML]
Genome-wide Association Studies (GWAS)
  • Old Notes:
  • Mapping trait loci by use of inferred ancestral recombination graphs [HTML]
  • Minichiello-durbin algorithm [pdf]
Haplotype Reconstruction
MCMC and the Population Genomics Substructure Problem
  • Old Notes:
  • Markov chains intro [pdf]
  • A tutorial on hidden Markov models [pdf]
Genomic Privacy Algorithms
  • New chapter, no notes
Causality and Prediction
  • New chapter, no notes